Antidepressants: placebos with side effects?
نویسندگان
چکیده
منابع مشابه
Active placebos versus antidepressants for depression.
BACKGROUND Although there is a consensus that antidepressants are effective in depression, placebo effects are also thought to be substantial. Side effects of antidepressants may reveal the identity of medication to participants or investigators and thus may bias the results of conventional trials using inert placebos. Using an 'active' placebo which mimics some of the side effects of antidepre...
متن کاملMeta-analysis of trials comparing antidepressants with active placebos.
BACKGROUND Unblinding effects may introduce bias into clinical trials. The use of active placebos to mimic side-effects of medication may therefore produce more rigorous evidence on the efficacy of antidepressants. METHOD Trials comparing antidepressants with active placebos were located. A standard measure of effect was calculated for each trial and weighted pooled estimates obtained. Hetero...
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We review the cardiovascular effects of newer antidepressants. Although further studies are warranted, the safety of the selective serotonin reuptake inhibitors and the serotonin norepinephrine reuptake inhibitors on patients with comorbid cardiac conditions is impressive. Newer antidepressants should be considered as first-line agents for the treatment of depression in patients with and withou...
متن کاملAntidepressants and Placebos: Secrets, Revelations, and Unanswered Questions
We are very heartened by the thoughtful responses to our article. Unlike some of the responses to a previous meta-analysis of antidepressant drug effects ( Kirsch & Sapirstein, 1998), there is now unanimous agreement among commentators that the mean difference between response to antidepressant drugs and response to inert placebo is very small. It is so small that, despite sample sizes involvin...
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In elderly patients, serotonin reuptake inhibitors seem to be safer and better tolerated than tricyclic antidepressants. The choice should be made on the basis of side effect profile and drug interactions. URRENT ANTIDEPRESSANT DRUGS are effective and generally well tolerated, but noncompliance remains worrisome. Up to 70% of patients taking antidepressants are noncompliant,1,2 as a result of e...
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ژورنال
عنوان ژورنال: Canadian Medical Association Journal
سال: 2010
ISSN: 0820-3946,1488-2329
DOI: 10.1503/cmaj.100772